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November 23 2016

Mangosteen is a fruit grown in Thailand and Myanmar whose rind (the mangosteen pericarp) appears to have some medicinal properties. The hull of the mangosteen fruit has been used for many years in Southeast Asia as a medicine for skin infection, wounds, and diarrhea, and recently other interesting properties of mangosteen are slowly being revealed. However, human trials are not available regarding mangosteen juice or mangosteen supplement, therefore we don’t know the benefit of mangosteen in clinical practice until studies are completed.

Where to buy mangosteen pills
If you would like to buy a mangosteen supplement to take on a daily basis, it may be a good idea to take a week off each month since long term human studies have not been done with this supplement. Mangosteen contains xanthones which have very interesting properties.

Buy Mangosteen product or learn the latest research. Additional herbs that have interesting properties include curcumin pill, goji berry, graviola supplement. Other supplements to consider include Noni fruit, and acai berry.

Mangosteen pill 500 mg (whole fruit) – Physician Formulas
Developed by Ray Sahelian, M.D.
Made from the highest quality mangosteen fruit material available, direct from Thailand. The actual active ingredients, xanthones, are mostly in the mangosteen rind and seed, and less in the mangosteen fruit flesh. We use the whole mangosteen fruit – rind, seed and flesh – in order to provide you with the full spectrum of xanthones. There are about 20 different xanthones in the whole fruit. Ninety-five percent of this mangosteen product is rind and seed.

Mangosteen Capsule Supplement Facts:
Mangosteen – 500 mg *
(Garcinia mangostana whole fruit, 95 percent is pericarp or rind)

Buy this Mangosteen product or to sign up to a highly popular and FREE Supplement Research newsletter. Twice a month we email a brief abstract of several studies on various supplements and natural medicine topics, including mangosteen juice and mangosteen supplement, and their practical interpretation by Ray Sahelian, M.D.

Suggested use: As a dietary supplement, take one mangosteen capsule daily or as recommended by your health care provider.
* Mangosteen supplement daily value not established.

Benefit of Mangosteen supplement
At this point almost all studies with mangosteen have been done in a laboratory and there is little human research to indicate how mangosteen supplements or mangosteen juice would influence the prevention or therapy of various cancers, including breast, lung, and liver, or what other benefit the compounds in mangosteen, such as xanthones, would have when ingested as a supplement. If you come across claims that mangosteen has been proven to have health benefit in humans, be skeptical. It may be true, but until actual long term human trials are done, we cannot be certain about mangosteen benefits or side effects.

What does the Mangosteen research say?
Mangosteen has compounds with antioxidant, anti-bacterial, anti-fungal, and anti-tumor activity. Laboratory testing thus far indicates that extracts of mangosteen have activity against several cancer cell lines including breast, liver, and leukemia. Mangosteen also appears to have anti-histamine and anti-inflammatory properties.

Benefit of Mangosteen Fruit versus the Mangosteen Rind
Most of the studies with mangosteen have focused on the pericarp, or the dark, woody rind as opposed to the fruit inside the woody rind. The pericarp contains the active xanthone compounds. The fruit itself probably has some beneficial compounds but the compounds within the mangosteen fruit have not been studied as well as the mangosteen rind.

What’s in Mangosteen Fruit?
Mangosteen fruit has a number of compounds, the most prominent being xanthones, a group of compounds that have antioxidant, anti-tumor, and other potent physiological properties.

What’s in Mangosteen plant
Several compounds in mangosteen appear to be active, particularly xanthones. Some of these xanthones include mangostin, mangostenol, mangostenone A, mangostenone B, trapezifolixanthone, tovophyllin B, alpha- and beta-mangostins, garcinone B, mangostinone, mangostanol, and the flavonoid epicatechin.

Mangosteen Research Update
Antioxidant xanthones from the pericarp of Garcinia mangostana ( Mangosteen ).

J Agric Food Chem. 2006. Jung HA, Su BN, Keller WJ, Mehta RG, Kinghorn AD.
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio
Garcinia mangostana ( commonly known as mangosteen ) was selected for detailed study. Repeated chromatography of a CH2Cl2-soluble extract of the pericarp led to the isolation of two new highly oxygenated prenylated xanthones, 8-hydroxycudraxanthone G and mangostingone, together with 12 known xanthones, cudraxanthone G, 8-deoxygartanin, garcimangosone B, garcinone D, garcinone E, gartanin (8), 1-isomangostin, alpha-mangostin, gamma-mangostin, mangostinone, smeathxanthone A, and tovophyllin A.

Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line.
Fitoterapia. 2004.
Ethanolic extracts of selected nine Thai medicinal plants were tested for antiproliferative activity against SKBR3 human breast adenocarcinoma cell line using MTT assay. Mangosteen showed the most potent activity.

Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.
Biol Pharm Bull. 2002.
The fruit hull of mangosteen, Garcinia mangostana L. has been used as a Thai indigenous medicine for many years. However, the mechanism of action of mangosteen as a medicine has not been elucidated. The present study was undertaken to examine the effects of mangosteen extracts (100% ethanol, 70% ethanol, 40% ethanol and water) on histamine release and prostaglandin E2 synthesis. We found that the 40% ethanol extract of mangosteen inhibited IgE-mediated histamine release from RBL-2H3 cells with greater potency than the water extract of Rubus suavissimus that has been used as an anti-allergy crude drug in Japan. All extracts of mangosteen potently inhibited A23187-induced prostaglandin E2 synthesis in C6 rat glioma cells, while the water extract of Rubus suavissimus had no effect. The 40% ethanol extract of mangosteen inhibited the prostaglandin E2 synthesis in a concentration-dependent manner with relatively lower concentrations than the histamine release. In addition, passive cutaneous anaphylaxis (PCA) reactions in rats were significantly inhibited by this ethanol extract as well as by the water extract of Rubus suavissimus. These results suggest that the 40% ethanol extract of mangosteen has potent inhibitory activities of both histamine release and prostaglandin E2 synthesis.

More Mangosteen information – The various forms of mangosteen sold
T
he active xanthones are in the pericarp (husk), and not the mangosteen fruit.
Mangosteen powder is sometimes added in juices to provide more xanthones to the juice mix. This “thickens” the mixture and adds more body. All mangosteen juice sellers refer to “shake” the bottle before drinking to mix the powder with the juice.

Extracts:
Mangosteen Extract – There are two common mangosteen extracts; alcohol extract and water based extracts. The extracts add more xanthones to the drink mixes which is the active ingredient in mangosteen.

Mangosteen Fruit Puree:
Whole mangosteen fruit is crushed and some water is added for pouring, and then put into plastic containers, frozen and then shipped from Thailand. Companies then add other fruit juices to improve taste.

Mangosteen Juice Concentrate:
This is “just add water” concentrate mix with only tropical fruit contents, No preservatives, No artificial colors, etc.

More mangosteen info
Known as the “Food of the gods” due to its exquisite flavor, the Mangosteen fruit has been described as tasting in between a strawberry-peach and vanilla ice-cream. So delicious is the Mangosteen fruit that legend speaks of Queen Victoria who offered a knighthood and handsome reward to anyone who could bring an edible Mangosteen back to England! But it’s the xanthone -packed rind and the many health benefits of the Mangosteen that is grabbing the attention of the health and functional food industry in the 21st century. Garcinia mangostana is closely related to but shouldn’t be confused with the button mangosteen and lemon drop mangosteen. Believed to have originated in the Moluccas and Sunda Islands, the Mangosteen trees are small evergreens found only in tropical areas such as Malaysia, Indonesia, Thailand and India. Its use for a variety of health conditions dates back to 600 AD. The trees reach heights of 7 to 25 metres, but are well know for being hard to grow and temperamental. In fact, the tree does not start producing fruit until around 15 years old. Thereafter, it will fruit until 100 years and beyond. The purple fruit rind is about the size of a tennis ball that when opened reveals an edible white, sweet and creamy flesh. Mature trees produce anywhere from 100-3000 fruits.

Mangosteen Health Benefits
The xanthones in mangosteen have excellent antioxidant values. Claims are made that mangosteen xanthones may help fight degenerative diseases such as cancer, heart disease, diabetes, arthritis and alzheimers and also protect the cardiovascular, skeletal and neurological systems. Promoters claim mangosteen has powerful anti-inflammatory properties. It prevents swelling and assists in the body’s healing process. It also has antibacterial properties and helps prevent hardening of the arteries.Mangosteen is useful for weight loss and promotes healthy cholesterol levels. It is used to treat fever, diarrhea, thrush, urinary disorders, and skin conditions like eczema. Mangosteen also promotes good vision, regulates menstruation and even acts as an anti-depressant!  However, no human studies are available to confirm these claims.

Nutrients, composition, ingredients
Mangosteen has been found to contain over 40 different xanthones, which are mostly concentrated in the pericarp. No other known plant offers the same quantity and variety of xanthones as Mangosteen. Each of these chemically beneficial molecules has their own specific qualities. Just to name a few, alpha-mangostin serves as an anti-oxidant, Garcinone E acts as an anti-tumor agent, and gamma-mangostin is an anti-inflammatory. Many of the beneficial xanthones found in mangosteen have been shown to possess antioxidative properties several times more powerful and potent than vitamin E and C. Mangosteen is also rich in vitamins and minerals such as vitamin C, B1, B2, B6, iron, fiber, protein, calcium, phosphorous, potassium, cathechins, tannins and niacin.

Mangosteen products offered by NP Nutra company
NP Nutra Mangosteen products are grown using organic compliant practices. A wide range of top quality Mangosteen products include:

*Mangosteen Super ORAC powder extract.
*Mangosteen Pericarp powder.
*Mangosteen 10:1 water soluble powder extract.
*Mangosteen Juice Concentrate 4:1.
And a variety of standardized Mangosteen extracts.

Mangosteen Juice and Mangosteen Fruit emails
Q. I would like to know how the mangosteen capsule compares to the juice.

A. The mangosteen capsules are pure mangosteen including the rind which has most of the active xanthones while the mangosteen juice has mostly the fruit and other fruit juices. Mangosteen capsules and mangosteen juice are different but there are no studies that compare the two in humans so it is difficult to say which is the healthier to take in the long.

Q. Are there any adverse affects such as cardiac arrhythmias or drug interactions with other meds with mangosteen?
A. There have not been any human studies with mangosteen, and thus far, we have not had feedback from consumers regarding such mangosteen side effects. This is all the information we have on mangosteen at this time. It is possible mangosteen side effects could come to light over time, but at this time, October 2006, no such mangosteen side effects have been reported in the medical literature or to us.

Q. I want to buy mangosteen, but before I do I wanted to know if mangosteen product is going to help me with urticaria hives that I’ve had been bothered by for 5 month now. I am using regular antihistamines and need a strong natural replacement. What do you recommend that would really help me and for once get rid of the cause of this skin problem? Also what dose is needs to be taken.
A. There are countless causes for urticaria or hives and buying mangosteen is not likely to be a solution.

Q. Does a mangosteen supplement use lead to weight loss?
A. We have not noticed mangosteen to have much of an effect on appetite. Hoodia is helpful in this regard.

Q. My husband has just been diagnosed with prostate cancer-early stage. During our research (before determining the treatment to chose) we heard mangosteen and it’s effects. I am aware that most items are more easily and completely absorbed in liquid form, however it seems the benefits we would benefit come from the rind of the fruit.
Would you please discuss whether we should buy mangosteen pills or should we buy the mangosteen juice liquid. Also any information you can give on prostate cancer & treatments would be greatly appreciated.
A. Since human studies have not been done comparing mangosteen capsules to mangosteen juice, one cannot say for certain which mangosteen form is better to buy. Mangosteen capsules have one advantage over the juice – the avoidance of extra calories and fructose found in the juice. See prostate cancer for info on this condition.

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