Chrysin flavonoid – Chrysin and testosterone release
December 22 2016

Chrysin is a natural, biologically active flavonoid compound extracted from many plants, honey and Propolis. For more chrysin information. Many people take chrysin supplements for body building purposes, but, as of 2017, we are not aware of any human studies that have shown that taking chrysin supplements lead to bigger or stronger muscles. We do know that creatine monohydrate supplements do work to improve muscle strength and muscle size.

Chrysin 500 mg supplement
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Chrysin (5,7-Dihydroxyflavone) is a bioflavonoid found in the plant Passiflora coerula, a member of the passion flower family.
Chrysin Supplement Facts:
Serving Size 1 Capsule
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Amount Per Capsule: Chrysin – 500 mg * (5, 7- Dihydroxyflavone)
Usage: Take 1 Chrysin capsule per day, or as directed by your qualified health consultant.
* Chrysin daily value not established

Benefits of Chrysin and medical uses
Chrysin supplement possesses potent anti-inflammation and anti-oxidation properties. Chrysin is able to stimulate nitric oxide release from endothelial cells leading to vascular cGMP accumulation and subsequent endothelium dependent vascular relaxation. Chrysin stimulated nitric oxide release is calcium independent and possibly mediated via PI3-kinase. There are claims that chrysin stimulates the release of testosterone. Since chrysin is available as an herbal supplement, some users, for instance body builders, are taking chrysin with the hope of raising testosterone levels or stimulating testosterone production. One study listed below did not find chrysin supplementation to lead to any significant increase in testosterone production.

Chrysin Research Update
Effects of the Flavonoid Chrysin on Nitrofurantoin Pharmacokinetics in Rats: Potential Involvement of ABCG2.
Drug Metab Dispos. 200; Wang X, Morris ME. University at Buffalo, State University of New York.
Breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette efflux transporter, important in drug disposition and in the development of multidrug resistance in cancer. Flavonoids, a large class of natural compounds widely present in the diet and herbal products, have been demonstrated in vitro as BCRP inhibitors. The flavonoid chrysin is a potent inhibitor of BCRP. Taken together, these results indicate that the flavonoid chrysin significantly inhibits nitrofurantoin transport mediated by human BCRP and murine Bcrp1. Bcrp1 inhibition by chrysin is likely one potential mechanism for the observed chrysin-nitrofurantoin pharmacokinetic interactions in rats.

Blood vessel dilation
Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.
J Vasc Res. 2004.
In the present study, the effects of the bioflavonoid chrysin (5,7-dihydroxyflavone) were analyzed on the perfusion pressure of isolated mesenteric vascular bed. The vasorelaxant effects of chrysin were more potent on intact endothelium than on denuded vessels. This endothelium-dependent response induced by chrysin was inhibited in the presence of N(G)-nitro-L-arginine methyl ester (L-NAME), KCl, tetraethylammonium (TEA), BaCl(2), TEA plus L-NAME, and ouabain plus BaCl(2), while incubations with indomethacin and glibenclamide did not modify the response induced by this bioflavonoid. Neither gap junction inhibition with carbenoxolone nor epoxyeicosatrieconic acid synthesis inhibition with sulfaphenazole (selective CYP 2C/3A inhibitor) or 7-ethoxyresorufin (selective CYP 1A inhibitor) inhibited the chrysin-induced relaxation. Moreover, chrysin increased L-NAME-sensitive cGMP accumulation in intact vascular mesenteric preparation. In conclusion, chrysin shows vasodilator effects on resistance vessels, which depend partially on the functional endothelium and appear to be related to the NO/cGMP pathway and, possibly to the release of endothelium-derived hyperpolarizing factor.

Testosterone levels
Effects of chrysin on urinary testosterone levels in human males.
J Med Food. 2003.
The equilibrium of sexual hormones in both sexes is controlled in vertebrates by the enzyme aromatase, a member of the cytochrome P450 superfamily, which catalyzes the conversion of androstenedione and testosterone into estrone and estradiol, respectively. Flavonoids are diphenolic compounds present in whole grains, legumes, fruits, and vegetables that are strongly implicated as protective in coronary heart disease, stroke, and cancer. One flavonoid, chrysin, found in high concentrations in honey and propolis, has been shown to be an inhibitor of aromatase enzyme activity. These foods are often used as supplements, particulary by sportsmen for their energetic and antioxidant properties. The aim of this study was to verify if daily treatment for 21 days with propolis and honey, containing chrysin, would modify urinary concentrations of testosterone in volunteer male subjects. In fact, aromatase inhibition by chrysin could block the conversion of androgens into estrogens with a consequent increase of testosterone, eventually measurable in urine samples. The obtained data did not show alterations of the levels of testosterone in the volunteers after 7, 14, and 21 days of treatment in comparison with baseline values and compared with measurements on the control subjects at the same time. In conclusion, the use of these foods for 21 days at the doses usually taken as oral supplementation does not have effects on the equilibrium of testosterone in human males.

To improve sexual drive see home Passion Rx

Chrysin and weight loss, appetite
Q. Does chrysin help with weight loss?
A. We have not seen such studies, but Green Tea Extract and hoodia seem to help.

Curcumin turmeric extract acts as antioxidant and antitumor