Serratiopeptidase Information
Health benefit and side effects of Serratiopeptidase enzyme

January 2 2017

Serratiopeptidase, an enzyme isolated from a microorganism in silkworm, is widely used in clinical practice in Japan. Until more is known about the long term benefit and side effects of serratiopeptidase, we recommend limiting daily dose to 20,000 units. We also suggest you take days off, for instance one day off a week and a few days off each month. Future research will give us clearer ideas of the ideal dosage of this supplement and more information on its safety profile.

SerratioPeptidase supplement to purchase
Buy Serrapeptase (also known as Serratio Peptidase or serratiopeptidase), a proteolytic enzyme. This enteric coated serratiopeptidase product by Physician Formulas is of the highest quality available. It is manufactured by a FDA approved facility. You can be sure you are getting exactly what you pay for.
Buy serratiopeptidase or sign up to a FREE newsletter by Ray Sahelian, M.D.

Serratiopeptidase, isolated from the microorganism Serratia E15,  is naturally present in the silkworm intestine which allows the emerging moth to dissolve its cocoon. Clinical use of serratiopeptidase in Europe and Asia spans over twenty five years.

Serrapeptase Supplement Facts
Serrapeptase – 200mg*
SerratioPeptidase (20,000 units enteric coated granules –  120,000 units per gram)
Serratiopeptidase daily value not established.

Serratiopeptidase summary and review
Serratiopeptidase appears to be a supplement with some clinical potential, however much more research is needed before we determine what clinical role this enzyme has in medicine. In the meantime, only use serratiopeptidase under medical supervision until more studies determine the full spectrum of serratiopeptidase side effects and benefits.

Conditions where serratiopeptidase has been studied
Chronic airway lung disease
Chronic ear, nose or throat disorders
Carpal tunnel syndrome
Serratiopeptidase has even been studied in certain cases of edema after an operation or injury.

Serratiopeptidase not helpful for dental pain
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.
Int J Oral Maxillofac Surg. 2009. Chopra D, Rehan HS, Mehra P, Kakkar AK. Department of Pharmacology, Lady Hardinge Medical College, New Delhi, India.
Assessment of postoperative sequelae following the removal of an impacted third molar tooth has been used in clinical pharmacology to evaluate the relative efficacy of various analgesic, anti-inflammatory drugs. This study included 150 patients with impacted lower third molars. They were randomly sorted to receive ibuprofen, paracetamol, betamethasone, serratiopeptidase or placebo. Betamethasone showed significant analgesic activity from day 1. Ibuprofen and betamethasone were significantly more effective than placebo in reducing swelling. Serratiopeptidase did not show significant analgesic and anti-inflammatory action.

Serratiopeptidase Research studies
Effect of the proteolytic enzyme serratiopeptidase in patients with chronic airway disease.
Respirology. 2003.
The proteolytic enzyme serratiopeptidase is widely used in clinical practice in Japan. We investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. This study was an open-labeled trial with a non-treatment control group. Patients were randomly assigned to oral treatment and without serratiopeptidase 30 mg/day for 4 weeks. Patients collected sputum samples for about 4 hours in the morning on the day the trial began and 4 weeks later. Part of each sputum sample was weighed and then completely dried and reweighed. The percentage solid component, viscosity and elasticity of the sputum were measured. Mucociliary transportability index was measured using ciliated bovine trachea ex vivo. After 4 weeks of serratiopeptidase treatment, sputum weight in the morning, percentage solid component, viscosity and elasticity of sputum, sputum neutrophil count, frequency of coughing and frequency of expectoration significantly decreased. Serratiopeptidase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.

A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome.
J Assoc Physicians India. 1999.
This study was planned to assess the response of serratiopeptidase in patients with carpal tunnel syndrome (CTS). Twenty patients with CTS were evaluated clinically. After baseline electrophysiological studies, these patients were given serrapeptase 10 mg twice daily with initial short course of nimesulide. Clinical and electrophysiological reassessment was done after 6 weeks. Sixty five percent of serratiopeptidase cases showed significant clinical improvement which was supported by improvement in electrophysiological parameters. Recurrence was reported in four cases. No significant side effect was observed. Serratiopeptidase therapy may proved to be a useful alternative mode of conservative treatment. Larger study may be further helpful to establish the role of serratiopeptidase in CTS. Serratiopeptidase therapy.

Q. I have been looking into the use of serratiopeptidase during my pregnancy to help with some varicose veins that have developed. My midwives said it is a completely natural product, but they see no studies supporting the safety of its use during pregnancy. Do you have any information regarding this, or could you direct me?
A. We have not seen any studies regarding the safety of serratiopeptidase during pregnancy.

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